Journal of Pharmaceutical and Medical Research
type: channel
description: Journal of Pharmaceutical and Medical Research (JPMR) is an international peer-reviewed, open access journal.
publisher: UPub Science
language: en
publication name: Journal of Pharmaceutical and Medical Research
issn: 2663-1954
items: PATIENT SATISFACTION WITH SMART MEDICAL SERVICES IN PUBLIC HOSPITALS OF XINXIANG CITY
items: IDENTIFICATION OF HYPERLIPIDEMIA RISK FACTORS AND QUANTIFICATION OF TCM CONSTITUTIONAL CONTRIBUTIONS: A MULTIDIMENSIONAL METRIC FRAMEWORK
items: MULTIMODAL STATISTICAL MODELING AND APPLICATION OF ROBOT-ASSISTED SURGERY PERFORMANCE EVALUATION BASED ON STACKED REGRESSION
items: MELATONIN: A POTENTIAL ATHLETIC PERFORMANCE MODULATOR
items: IDENTIFICATION OF NOCTURNAL HYPOGLYCEMIA BY FLASH GLUCOSE MONITORING IN PRIMARY CARE: A CASE REPORT AND REVIEW OF THE LITERATURE
items: BIDIRECTIONAL TWO-SAMPLE MENDELIAN RANDOMIZATION STUDY OF AUTOIMMUNE HEPATITIS AND PREMATURE OVARIAN INSUFFICIENCY
items: THE ROLE AND THERAPEUTIC STRATEGIES OF PRECURSOR EXHAUSTED CD8-positive T CELLS IN TUMOR IMMUNITY
items: CURRENT STATUS OF CLINICAL USE OF ANTIBACTERIAL DRUGS AND RESEARCH ON COUNTERMEASURES AGAINST DRUG RESISTANCE
items: ALKANNIN AND ITS INHIBITORY ACTIVITY AGAINST STARCH HYDROLASES
items: COMPUTER PREDICTION, MOLECULAR DOCKING, AND BINDING MODEL ANALYSIS OF ANTIOXIDANT POTENTIAL IN BAIJIU DISTILLER’S GRAIN PROTEIN HYDROLYSATES
items: RESEARCH PROGRESS IN THE DIAGNOSIS AND TREATMENT OF MULTIPLE MYELOMA
items: CLINICAL EVALUATION OF AN 18-LEAD ECG DEVICE'S PERFORMANCE AND SAFETY: A PROSPECTIVE PAIRED-DEVICE STUDY
items: RESEARCH PROGRESS ON THE APPLICATION OF PHASE ANGLE IN POSTOPERATIVE COMPLICATIONS OF LUNG CANCER
items: TERAHERTZ TECHNOLOGY IN TUMOR THERAPY: MECHANISMS, APPLICATIONS IN HEPATOCELLULAR CARCINOMA, AND FUTURE PROSPECTS
items: THEORETICAL EXPLORATION OF YIQI HUAYU JIEDU THERAPY COMBINED WITH TRASTUZUMAB AND CHEMOTHERAPY IN THE TREATMENT OF ENDOMETRIAL CANCER
items: MUSCLE ENERGY TECHNIQUE(MET) COMBINED WITH KINESIO TAPING FOR FUNCTIONAL RECOVERY IN PATIENTS WITH ANKLE SPRAIN: A RANDOMIZED CONTROLLED TRIAL
items: FROM GUT TO BRAIN: TARGETING THE MICROBIOTA AXIS FOR NOVEL THERAPEUTIC AVENUES IN PARKINSON’S DISEASE
items: EVALUATION OF PERFORMANCE AND SAFETY OF THE 12-LEAD ECG: A PROSPECTIVE SIMULTANEOUS PAIRED COMPARATIVE STUDY
items: TREM1 PROMOTES GASTRIC CANCER METASTASIS AND LEADS TO POOR PROGNOSIS IN PATIENTS THROUGH THE ERK/IL-6 SIGNALING PATHWAY
items: EXPRESSION AND CLINICAL SIGNIFICANCE OF LHPP IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA
items: NURSING EFFECT OF TRADITIONAL CHINESE MEDICINE SMEARING ON RADIATION SKIN INJURY IN A PATIENT WITH BREAST CANCER
items: PROGRESS AND MECHANISMS OF ANTIBODY-DRUG CONJUGATES IN NSCLC THERAPY
items: PRETREATMENT ULTRASOUND-BASED RADIOMICS NOMOGRAM FOR PREDICTING PATHOLOGICAL COMPLETE RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN HER2-POSITIVE BREAST CANCER
items: NON-INVASIVE PRENATAL DETECTION MODEL FOR FEMALE FETAL CHROMOSOMAL ANEUPLOIDY BASED ON XGBOOST
items: REGRESSION ANALYSIS-BASED INVESTIGATION OF FACTORS INFLUENCING MALE FETAL Y CHROMOSOME CONCENTRATION AND STRATIFIED OPTIMIZATION OF OPTIMAL TIMING FOR NON-INVASIVE PRENATAL TESTING
items: THE ANIMAL MODEL ESTABLISHMENT METHODS AND MODEL EVALUATION FOR LIVER STAGNATION AND SPLEEN DEFICIENCY SYNDROME
items: ANALYSIS OF THE STATUS OF NEWLY REPORTED OCCUPATIONAL DISEASES IN EMPLOYING UNITS IN A CERTAIN CITY FROM 2015 TO 2024
items: MECHANISM STUDY OF SHENFU INJECTION REGULATING MAPK PATHWAY TO ALLEVIATE MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RATS BASED ON BIOINFORMATICS AND EXPERIMENTAL VERIFICATION
items: EXPRESSION AND CLINICAL SIGNIFICANCE OF GLYCEROL KINASE (GK) IN ESOPHAGEAL CARCINOMA
items: ADVANCES IN THE APPLICATION OF DEEP LEARNING IN CERVICAL OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT

PATIENT SATISFACTION WITH SMART MEDICAL SERVICES IN PUBLIC HOSPITALS OF XINXIANG CITY
type: item
description: In response to the lack of empirical research on smart healthcare in public hospitals in prefecture level cities in northern Henan, this article selects representative tertiary public hospitals in Xinxiang City as research samples, focusing on the pain points of patient experience and satisfaction after the implementation of smart healthcare. Build an evaluation framework using TAM technology acceptance model, perceived risk theory, and SERVQUAL service quality model. Conduct on-site questionnaire surveys combined with SPSS statistical analysis, and use descriptive statistics, correlation analysis, variance testing, and multiple regression to conduct empirical calculations. The survey shows that the utilization rate of smart healthcare among surveyed patients is 91.67%, with an overall satisfaction score of 3.68; The lack of publicity, system failure and privacy concerns significantly lower the evaluation, and the high frequency online services, high education and urban registered residence are positively improving the satisfaction. The research results can provide empirical reference for optimizing smart services and improving patient medical experience in public hospitals in northern Henan.
subject: Research Article
  topic: section
subject: Public hospitals
  topic: keywords
subject: Smart healthcare
  topic: keywords
subject: Patient satisfaction
  topic: keywords
subject: TAM model
  topic: keywords
creator: SiQian Chen
creator: Xiang Sun
rights: Copyright (c) 2026 SiQian Chen; Xiang Sun https://creativecommons.org/licenses/by/4.0
date: 2026-06-08
publication date: 2026-06-08
starting page: 30
ending page: 34
doi: 10.61784/jpmr3082

IDENTIFICATION OF HYPERLIPIDEMIA RISK FACTORS AND QUANTIFICATION OF TCM CONSTITUTIONAL CONTRIBUTIONS: A MULTIDIMENSIONAL METRIC FRAMEWORK
type: item
description: Against the backdrop of rising hyperlipidemia prevalence and limited management resources, the precise identification of key risk factors in high-risk populations is of great significance for improving public health. Based on clinical data from 1,000 middle-aged and elderly patients, this study constructed a composite measurement framework combining linear contraction and nonlinear evaluation, aiming to systematically identify core risk indicators for hyperlipidemia and assess the marginal contribution of Traditional Chinese Medicine (TCM) constitutions. The study first employed a LASSO regression model with L1 regularization to perform embedded screening of the initial high-dimensional features, effectively overcoming the interference of multicollinearity among lipid indicators. Subsequently, supplementary validation was conducted by integrating importance rankings from random forests, ultimately identifying eight core early warning indicators, including total cholesterol (TC), triglycerides (TG), BMI, and the total score of the physical activity questionnaire. These indicators demonstrated strong clinical predictive utility. Regarding the quantification of constitutional risk contributions, to address statistical biases caused by mixed constitutions, the study introduced a regularized logistic regression model with signed constraints for corrective estimation. Empirical results indicate that the Phlegm-Dampness constitution is the susceptibility factor with the highest risk of disease onset and the greatest statistical significance, with an odds ratio of 1.15, while the Harmonious constitution exhibits a clear health-protective effect. This study provides empirical evidence for the development of an early warning system for chronic diseases that deeply integrates traditional Chinese medicine (TCM) and Western medicine.
subject: Research Article
  topic: section
subject: Hyperlipidemia
  topic: keywords
subject: LASSO feature selection
  topic: keywords
subject: TCM constitution risk
  topic: keywords
subject: Odds ratio measurement
  topic: keywords
creator: JunXiang Luo
creator: ZiJian Chen
creator: ZiMu Huang
rights: Copyright (c) 2026 JunXiang Luo; ZiJian Chen; ZiMu Huang https://creativecommons.org/licenses/by/4.0
date: 2026-06-06
publication date: 2026-06-06
starting page: 23
ending page: 29
doi: 10.61784/jpmr3081

MULTIMODAL STATISTICAL MODELING AND APPLICATION OF ROBOT-ASSISTED SURGERY PERFORMANCE EVALUATION BASED ON STACKED REGRESSION
type: item
description: With the wide application of Robot-Assisted Surgery (RAS) technology, accurate and objective surgical performance evaluation has become the key to optimizing surgical effects and reducing medical risks. Aiming at the problems of strong subjectivity and insufficient accuracy of existing evaluation methods, this paper integrates electroencephalography (EEG) and eye-tracking multimodal data to construct a set of robot-assisted surgery performance evaluation models. First, the original data are normalized, feature extracted and dimensionality reduced to eliminate data heterogeneity and redundancy; then, Support Vector Regression (SVR) and Multilayer Perceptron (MLP) are used as base learners, combined with Newton's iteration method to optimize parameters, to construct a stacked regression model, and linear regression and LSTM models are introduced as controls to carry out comparative experiments; finally, the model performance is quantitatively evaluated by indicators such as Root Mean Square Error (RMSE), Mean Absolute Error (MAE) and F1-Score. The experimental results show that the proposed stacked regression model is significantly superior to the control models in evaluation accuracy, with RMSE 0.23 lower than that of traditional linear regression and MAE 0.11 lower, which can accurately describe the cognitive and behavioral states of doctors during surgical operations. This study provides a reliable technical method and data support for robot-assisted surgery performance evaluation, and has important theoretical value and practical significance for promoting the optimization of surgical technology and improving medical quality.
subject: Research Article
  topic: section
subject: Robot-assisted surgery
  topic: keywords
subject: Stacked regression
  topic: keywords
subject: Multimodal data
  topic: keywords
subject: Performance evaluation
  topic: keywords
subject: Support vector regression
  topic: keywords
creator: HaoYu Tian
rights: Copyright (c) 2026 HaoYu Tian https://creativecommons.org/licenses/by/4.0
date: 2026-06-06
publication date: 2026-06-06
starting page: 16
ending page: 22
doi: 10.61784/jpmr3080

MELATONIN: A POTENTIAL ATHLETIC PERFORMANCE MODULATOR
type: item
description: Melatonin secreted by the pineal gland plays a crucial role in human biological activities. The rhythm of melatonin is closely related to athletic performance. In recent years, some studies have elucidated the relationship between melatonin and athletic function, but the potential enhancing effects of melatonin on improving athletic performance have not been widely noted. This article narratively reviews the impact of melatonin on different physical qualities, different types of athletic performance and their rhythmicity, and the potential mechanisms by which melatonin affects athletic performance, and then sorts out the role of melatonin in optimizing athletic performance.
subject: Research Article
  topic: section
subject: Melatonin
  topic: keywords
subject: Athletic performance
  topic: keywords
subject: Physical qualities
  topic: keywords
creator: DeFeng Wu
creator: PeiYi Wang
creator: Lian Guan
rights: Copyright (c) 2026 DeFeng Wu; PeiYi Wang; Lian Guan https://creativecommons.org/licenses/by/4.0
date: 2026-06-02
publication date: 2026-06-02
starting page: 7
ending page: 15
doi: 10.61784/jpmr3079

IDENTIFICATION OF NOCTURNAL HYPOGLYCEMIA BY FLASH GLUCOSE MONITORING IN PRIMARY CARE: A CASE REPORT AND REVIEW OF THE LITERATURE
type: item
description: Objective: To explore the clinical value of flash glucose monitoring (FGM) in community-based diabetes management through analysis of a case of nocturnal hypoglycemia identified by FGM. Methods: A retrospective analysis was conducted on the clinical data of a 74-year-old male patient with type 2 diabetes mellitus. Because of persistently elevated fasting blood glucose levels (7.0-9.0 mmol/L), the patient had been self-adjusting multiple oral hypoglycemic agents over a prolonged period, including acarbose, sitagliptin phosphate, glipizide controlled-release tablets, dapagliflozin, and pioglitazone/metformin. FGM revealed nocturnal hypoglycemia, confirming the presence of the Somogyi phenomenon. Assessment using the Chinese version of the Diabetes Management Self-Efficacy Scale (C-DMSES) indicated low self-efficacy. Results: Based on the FGM findings, the glucose-lowering regimen was adjusted by discontinuing glipizide controlled-release tablets and pioglitazone/metformin. Individualized dietary and exercise prescriptions, smoking cessation counseling, and psychological support were also provided. After intervention, the antidiabetic regimen was simplified, and no hypoglycemic events were detected on follow-up FGM. At 3 months, fasting blood glucose was 6.8 mmol/L, 2-hour postprandial blood glucose was 9.4 mmol/L, and glycated hemoglobin (HbA1c) was 6.9%. In addition, the C-DMSES score improved significantly. Conclusion: FGM can effectively identify unrecognized nocturnal hypoglycemia in community-dwelling patients with diabetes and provide an objective basis for individualized and precise comprehensive management. For patients receiving multiple glucose-lowering agents and demonstrating low self-efficacy, FGM combined with a general practitioner-specialist collaborative care model may facilitate safe achievement of glycemic targets.
subject: Research Article
  topic: section
subject: Type 2 diabetes mellitus
  topic: keywords
subject: Flash glucose monitoring
  topic: keywords
subject: Hypoglycemia
  topic: keywords
subject: Somogyi phenomenon
  topic: keywords
subject: Community management
  topic: keywords
creator: XiuYing Mao
creator: Lan Shen
creator: NaNa Wang
creator: HaiYing Zhang
creator: Hua Yu
creator: Ling Zhang
creator: Ning Wang
creator: HuiHua Jin
creator: Jiang Yue
rights: Copyright (c) 2026 XiuYing Mao; Lan Shen; NaNa Wang; HaiYing Zhang; Hua Yu; Ling Zhang; Ning Wang; HuiHua Jin; Jiang Yue https://creativecommons.org/licenses/by/4.0
date: 2026-06-01
publication date: 2026-06-01
starting page: 1
ending page: 6
doi: 10.61784/jpmr3078

BIDIRECTIONAL TWO-SAMPLE MENDELIAN RANDOMIZATION STUDY OF AUTOIMMUNE HEPATITIS AND PREMATURE OVARIAN INSUFFICIENCY
type: item
description: Objective: To explore the bidirectional causal relationship between autoimmune hepatitis (AIH) and premature ovarian insufficiency (POI) by bidirectional Mendelian randomization (MR). Methods: Bidirectional MR analysis was used to explore the causal effect of AIH as the exposure factor and POI as the outcome index in the forward direction, and POI as the exposure factor and AIH as the outcome index in the reverse direction. Genome-wide association study (GWAS) data for AIH and POI were obtained from the IEU Open GWAS database. Single nucleotide polymorphisms (SNPs) that were strongly associated and independent were selected as instrumental variables (IVs) according to a predefined threshold. The causal association between AIH and POI was evaluated using inverse variance weighted (IVW), MR-Egger regression, weighted median, simple mode, and weighted mode methods. Heterogeneity among SNPs was assessed using Cochran's Q test. The MR-PRESSO test was applied to detect potential outlier SNPs. Horizontal pleiotropy was examined using the MR-Egger intercept test. A leave-one-out sensitivity analysis was performed to determine whether the MR results were driven by any single SNP. Results: The IVW analysis in the forward MR revealed no causal relationship between AIH and the onset of POI (OR = 1.06, 95% CI:0.88-1.29, P = 0.54). In the reverse MR, the IVW analysis indicated a statistically significant association between genetically predicted POI and a reduced risk of AIH (OR = 0.94, 95% CI:0.89-0.99, P = 0.02). No evidence of horizontal pleiotropy or heterogeneity was detected for any instrumental variable in the bidirectional MR analysis. Conclusion: The forward MR analysis does not support a causal effect of AIH on POI. The reverse MR analysis suggests that POI may reduce the risk of AIH. However, the observed effect size is small. This causal inference requires cautious interpretation. Future studies with larger sample sizes are needed for validation.
subject: Research Article
  topic: section
subject: Autoimmune hepatitis
  topic: keywords
subject: Premature ovarian insufficiency
  topic: keywords
subject: Bidirectional Mendelian randomization
  topic: keywords
creator: Na Jiang
creator: MinCai Li
rights: Copyright (c) 2026 Na Jiang; MinCai Li https://creativecommons.org/licenses/by/4.0
date: 2026-05-11
publication date: 2026-05-11
starting page: 56
ending page: 62
doi: 10.61784/jpmr3077

THE ROLE AND THERAPEUTIC STRATEGIES OF PRECURSOR EXHAUSTED CD8-positive T CELLS IN TUMOR IMMUNITY
type: item
description: The clinical use of immune checkpoint inhibitors (ICIs) has markedly improved outcomes in a range of malignancies. Even so, overall response rates remain unsatisfactory, and acquired resistance often erodes durable clinical benefit. Accumulating evidence suggests that terminally exhausted CD8-positive T cells are not the principal population that expands after checkpoint blockade. Rather, precursor exhausted CD8-positive T cells (Tpex), which retain self-renewal capacity and the potential to redifferentiate, provide the main cellular foundation for sustained antitumor immunity. In most settings, Tpex are characterized by high TCF1 expression, relatively low levels of terminal exhaustion markers, and responsiveness to PD-1 blockade. Their generation and persistence are shaped by several interconnected factors, including tumor-draining lymph nodes, intratumoral antigen-presenting cell niches, transcription factor circuits, metabolic adaptation, and epigenetic remodeling. Research on Tpex is now reshaping the conceptual basis of cancer immunotherapy. The emphasis is shifting away from simply amplifying immune activation and toward expanding the precursor pool, preserving cellular plasticity, and modulating the timing of differentiation. This review outlines the conceptual definition, biological basis, fate-regulatory mechanisms, and translational significance of Tpex in tumor immunotherapy. It also discusses current challenges, such as the absence of a unified phenotypic definition, the shortage of longitudinal causal evidence, and the still-limited body of clinical translational data. Overall, this review aims to provide a useful framework for refining precision immunotherapeutic strategies.
subject: Research Article
  topic: section
subject: CD8-positive T cells
  topic: keywords
subject: Precursor exhausted T cells
  topic: keywords
subject: Tumor immunity
  topic: keywords
subject: Immune checkpoint inhibitors
  topic: keywords
creator: ShuHua Chen
creator: YaJie Lu
creator: JuLiang Zhang
creator: DongHui Wang
rights: Copyright (c) 2026 ShuHua Chen; YaJie Lu; JuLiang Zhang; DongHui Wang https://creativecommons.org/licenses/by/4.0
date: 2026-05-09
publication date: 2026-05-09
starting page: 47
ending page: 55
doi: 10.61784/jpmr3076

CURRENT STATUS OF CLINICAL USE OF ANTIBACTERIAL DRUGS AND RESEARCH ON COUNTERMEASURES AGAINST DRUG RESISTANCE
type: item
description: Antimicrobial drugs are the main means of treating bacterial infections in clinical practice and play an important role in protecting human health. However, with the large-scale use and even rampant abuse of antimicrobial drugs in the medical, animal husbandry, and agricultural fields, the problem of bacterial resistance is becoming increasingly intractable and has now evolved into a global public health crisis. This article analyzes the current status and characteristics of the clinical application of antimicrobial drugs, explores the diverse mechanisms and harms of drug resistance, and proposes systematic prevention and control measures from multiple levels, including medical standards, technological innovation, and policy supervision, based on the latest research results and management experience at home and abroad. The aim is to provide theoretical basis and practical reference for preventing the spread of drug resistance and enhancing the level of rational use of antimicrobial drugs.
subject: Research Article
  topic: section
subject: Antibacterial drugs
  topic: keywords
subject: Clinical application
  topic: keywords
subject: Drug resistance
  topic: keywords
subject: Rational use
  topic: keywords
creator: DaCheng Sun
creator: Shuang Xu
rights: Copyright (c) 2026 DaCheng Sun; Shuang Xu https://creativecommons.org/licenses/by/4.0
date: 2026-04-28
publication date: 2026-04-28
starting page: 43
ending page: 46
doi: 10.61784/jpmr3075

ALKANNIN AND ITS INHIBITORY ACTIVITY AGAINST STARCH HYDROLASES
type: item
description: This study optimized the ethanol-based ultrasonic-assisted extraction process of alkannin and evaluated its inhibitory activity and mechanism against α-amylase and α-glucosidase. The suitable ranges for various factors were determined through single-factor experiments. Subsequently, the Plackett-Burman design was employed to screen for significant factors, combined with the steepest ascent design to approach the optimal region, and the Box-Behnken design was utilized to optimize the extraction conditions. Finally, enzyme inhibition assays and molecular docking were conducted to investigate its activity and mechanism. The results indicated that the liquid-to-solid ratio, ultrasonic time, and ethanol volume fraction were significant influencing factors. The optimal extraction conditions were determined as follows: a liquid-to-solid ratio of 10:1 (mL/g), an ethanol volume fraction of 90.5%, an ultrasonic time of 45 min, and 2 extraction cycles. Under these conditions, the extraction yield of alkannin reached 1.952%. The half-maximal inhibitory concentration (IC₅₀) values of alkannin against α-amylase and α-glucosidase were 2.729 μM and 1.409 μM, respectively. Molecular docking revealed that alkannin exhibited non-competitive inhibition against α-amylase (binding energy: -6.9 kcal·mol⁻¹) and competitive inhibition against α-glucosidase (binding energy: -7.8 kcal·mol⁻¹). This study provides an experimental basis for the extraction process optimization and enzymatic inhibitory activity of alkannin.
subject: Research Article
  topic: section
subject: Alkannin
  topic: keywords
subject: Ultrasonic-assisted extraction
  topic: keywords
subject: Single-factor experiment
  topic: keywords
subject: Response surface methodology
  topic: keywords
subject: α-Amylase
  topic: keywords
subject: α-Glucosidase
  topic: keywords
subject: Molecular docking
  topic: keywords
creator: YuJin Liu
creator: WenTing Yang
creator: ZiYing Yang
creator: ZiYi Zhang
creator: WenJing Yao
creator: Pin Guo
creator: Ang Zhang
rights: Copyright (c) 2026 YuJin Liu; WenTing Yang; ZiYing Yang; ZiYi Zhang; WenJing Yao; Pin Guo; Ang Zhang https://creativecommons.org/licenses/by/4.0
date: 2026-04-21
publication date: 2026-04-21
starting page: 31
ending page: 42
doi: 10.61784/jpmr3074

COMPUTER PREDICTION, MOLECULAR DOCKING, AND BINDING MODEL ANALYSIS OF ANTIOXIDANT POTENTIAL IN BAIJIU DISTILLER’S GRAIN PROTEIN HYDROLYSATES
type: item
description: To efficiently utilize antioxidant peptides from Baijiu distiller’s grain protein hydrolysates, this study used Baijiu distiller’s grain protein hydrolysate as raw material and analyzed the molecular weight distribution via SEC-HPLC across ranges of ≥70 kDa, 10–70 kDa, 5–10 kDa, 1–5 kDa, 0. 2–1 kDa, and ≤0. 2 kDa. Results showed that the hydrolysates were dominated by small-molecule peptides below 1 kDa with uniform distribution. Subsequently, peptide sequences were identified by LC-MS/MS, and virtual screening combined with bioinformatics prediction yielded eight candidate peptides: PYPR, YPR, DPHG, YGPR, KWY, GRLPGYG, PRY, and YPVPR. All peptides exhibited favorable bioactivity scores, water solubility, and no toxicity or allergenicity. Antioxidant prediction revealed that PYPR had the highest free radical scavenging score (0. 551), and DPHG showed optimal metal chelating activity (0. 323). Molecular docking demonstrated that the binding energies of the eight peptides to Keap1 protein ranged from −8. 0 to −10. 3 kcal/mol. Among them, YGPR had the lowest binding energy (−10. 3 kcal/mol) and formed up to 10 hydrogen bonds, indicating the strongest binding capacity. This study rapidly screened eight high-potential antioxidant peptides from Baijiu distiller’s grain protein using a computer-assisted strategy, providing a theoretical basis and an efficient screening method for resource utilization of Baijiu distiller’s grain protein and development of food-derived antioxidant peptides.
subject: Research Article
  topic: section
subject: Baijiu distiller’s grain
  topic: keywords
subject: Virtual screening
  topic: keywords
subject: Molecular docking
  topic: keywords
subject: Antioxidant
  topic: keywords
creator: Yue Zheng
creator: WenJia Chen
creator: JunXian Li
creator: Rui Liu
creator: Liang Dong
rights: Copyright (c) 2026 Yue Zheng; WenJia Chen; JunXian Li; Rui Liu; Liang Dong https://creativecommons.org/licenses/by/4.0
date: 2026-04-20
publication date: 2026-04-20
starting page: 21
ending page: 30
doi: 10.61784/jpmr3073

RESEARCH PROGRESS IN THE DIAGNOSIS AND TREATMENT OF MULTIPLE MYELOMA
type: item
description: Multiple myeloma (MM) is a hematologic disorder characterized by clonal abnormal proliferation of malignant plasma cells in the bone marrow, accompanied by the presence of monoclonal immunoglobulins or their fragments in the blood and urine. The most important tools for diagnosing MM include molecular diagnosis, bone marrow cytology, and imaging, etc. The early symptoms of MM are atypical and easily misdiagnosed or missed, and need to be combined with several laboratory tests to make a comprehensive judgment. In recent years, research on oncogenesis, cytogenetics and molecular biology has been fruitful, and a variety of biomarkers such as microRNA, circulating tumor cells, circulating free DNA, circulating tumor DNA, etc. have been found to be related to multiple myeloma, which can be used for the auxiliary diagnosis of MM, predicting disease progression or for subsequent therapeutic targets. And with the development of science and technology, artificial intelligence and machine learning can also assist physicians in analysis and diagnosis. Meanwhile, monoclonal antibody therapies, targeting B-cell maturation antigens, etc. have also been shown to have better clinical efficacy in the treatment of multiple myeloma. The purpose of this article is to review the laboratory tests that are important for the diagnosis of multiple myeloma and the treatment options for the disease, to provide a basis and direction for the clinical diagnosis and treatment of multiple myeloma, and to improve the detection rate and efficacy of multiple myeloma.
subject: Research Article
  topic: section
subject: Multiple myeloma
  topic: keywords
subject: Diagnosis
  topic: keywords
subject: Treatment
  topic: keywords
creator: YiFan Ding
creator: Hu Xiao
rights: Copyright (c) 2026 YiFan Ding; Hu Xiao https://creativecommons.org/licenses/by/4.0
date: 2026-04-13
publication date: 2026-04-13
starting page: 16
ending page: 20
doi: 10.61784/jpmr3072

CLINICAL EVALUATION OF AN 18-LEAD ECG DEVICE'S PERFORMANCE AND SAFETY: A PROSPECTIVE PAIRED-DEVICE STUDY
type: item
description: This prospective, single-center study was designed to validate the clinical performance and safety of the Zoncare iMAC1800pro (iMAC-Series) 18-lead digital multi-channel electrocardiograph, with the ED** SE-18 as the reference standard. A total of 154 participants were enrolled and stratified into three cohorts: normal ECG (n=54), arrhythmia (n=50), and ST-segment abnormality (n=50). Each subject underwent simultaneous 18-lead ECG recordings using both devices, which were connected to the same set of skin electrodes via a standard passive Y-lead splitter cable. Key parameters including heart rate, PR interval, QRS duration, QT interval, QTc value, P-wave axis, QRS axis, T-wave axis, and ST-segment deviation were automatically measured by both systems and manually verified by senior cardiologists (with senior professional titles and more than 10 years of ECG diagnostic experience). The Zoncare iMAC1800pro showed clinical equivalence to the reference device in all measured parameters, with no statistically significant differences (P > 0.05). ST-segment elevation/depression and the maximum elevation/depression amplitude (all P > 0.05), indicating excellent consistency between the two devices in ST-segment deviation measurement. No device-related adverse events or equipment malfunctions were reported during the study. These findings confirm the clinical reliability and safety of the Zoncare iMAC1800pro for routine electrocardiographic assessment.
subject: Research Article
  topic: section
subject: Electrocardiography
  topic: keywords
subject: 18-Lead ECG
  topic: keywords
subject: Diagnostic accuracy
  topic: keywords
subject: Medical device validation
  topic: keywords
subject: ST-segment analysis
  topic: keywords
subject: Cardiac safety
  topic: keywords
creator: Bo Zhang
creator: Tao Zhu
creator: Tao Hu
creator: Jing Li
creator: ZiYan Wan
rights: Copyright (c) 2026 Bo Zhang; Tao Zhu; Tao Zhu; Jing Li; ZiYan Wan https://creativecommons.org/licenses/by/4.0
date: 2026-03-31
publication date: 2026-03-31
starting page: 8
ending page: 15
doi: 10.61784/jpmr3071

RESEARCH PROGRESS ON THE APPLICATION OF PHASE ANGLE IN POSTOPERATIVE COMPLICATIONS OF LUNG CANCER
type: item
description: Phase angle (PhA) is the result of bioresistivity analysis (BIA) and is a physiological marker. In the past few years, the field of medical research has attracted more and more attention. In the field of oncology, PhA is particularly useful because it is related to the nutritional status and cell integrity of patients, and provides an important estimate of the risk of postoperative complications in surgical lung cancer population. Existing research shows that there may be a link between PhA and postoperative complications in lung cancer patients, but so far, research has been limited in terms of small sample size or lack of standard methods for evaluating PhA. This review outlines the physiological basis of PhA, the methods of measuring PhA, and the possibility of PhA affecting the risk of postoperative complications in patients with postoperative lung cancer. This review expands the study to integrate the latest articles published before to discuss the potential value and opportunities of using PhA in risk assessment in the future. This review ultimately aims to solve the current relationship between PhA and postoperative complications, evaluate the use of influencing factors or clinical interventions, and inform the basic practice of the evidence of lung cancer population in the postoperative nursing environment.
subject: Research Article
  topic: section
subject: Phase angle
  topic: keywords
subject: Lung cancer
  topic: keywords
subject: Postoperative complications
  topic: keywords
subject: Bioelectrical impedance analysis
  topic: keywords
subject: Risk prediction
  topic: keywords
subject: Nutritional assessment
  topic: keywords
creator: DeXin Luo
creator: Rui Lan
creator: ShuYu Kuang
creator: Chun Huang
rights: Copyright (c) 2026 DeXin Luo; Rui Lan; ShuYu Kuang; Chun Huang https://creativecommons.org/licenses/by/4.0
date: 2026-03-27
publication date: 2026-03-27
starting page: 1
ending page: 7
doi: 10.61784/jpmr3070

TERAHERTZ TECHNOLOGY IN TUMOR THERAPY: MECHANISMS, APPLICATIONS IN HEPATOCELLULAR CARCINOMA, AND FUTURE PROSPECTS
type: item
description: Terahertz(THz) technology, as a emerging non-ionizing electromagnetic wave therapy, has made significant progress in the field of tumor treatment in recent years. With its unique low-energy, non-ionizing characteristics and high sensitivity to biological tissues, THz technology can act on tumor cells without damaging normal cells and produce a series of biological effects, such as changes in cell membrane permeability, vibrations of protein molecules, and effects on telomeres and telomerase, thereby inhibiting tumor cell proliferation or inducing apoptosis. Compared with traditional surgery, chemotherapy, and radiotherapy, THz technology, with its high selectivity and low side effects, provides a safer and more precise treatment option for cancer patients. This review aims to summarize the latest advances in THz technology for tumor treatment, deeply explore its mechanisms of action, technical advantages, and clinical application prospects. At the same time, this paper will also analyze the current technical challenges, such as the penetration depth of THz waves, equipment costs, and optimization of treatment parameters, and look forward to further development of THz technology in tumor treatment in the context of multi-disciplinary integration, providing reference for related research and clinical applications.
subject: Research Article
  topic: section
subject: Terahertz
  topic: keywords
subject: Non-ionizing characteristics
  topic: keywords
subject: Protein molecular vibration
  topic: keywords
subject: Low side effects
  topic: keywords
creator: XiaoYang Shi
creator: ShuQun Cheng
rights: Copyright (c) 2026 XiaoYang Shi; ShuQun Cheng https://creativecommons.org/licenses/by/4.0
date: 2026-03-27
publication date: 2026-03-27
starting page: 60
ending page: 66
doi: 10.61784/jpmr3069

THEORETICAL EXPLORATION OF YIQI HUAYU JIEDU THERAPY COMBINED WITH TRASTUZUMAB AND CHEMOTHERAPY IN THE TREATMENT OF ENDOMETRIAL CANCER
type: item
description: Endometrial cancer is a common female reproductive system malignancy with rising morbidity and mortality annually. Trastuzumab combined with paclitaxel and carboplatin chemotherapy is the standard regimen for HER2 - positive endometrial cancer, exerting anti - tumor effects by blocking HER2 signaling, inhibiting JAK/STAT pathway activation, and downregulating PD - L1 expression. However, it has limitations such as severe adverse events and acquired drug resistance. According to TCM theory, endometrial cancer is related to "beng lou" and "zheng jia", with a core pathogenesis of vital qi deficiency and retention of damp - heat, blood stasis, and toxin in the uterus. Yiqi Huayu Jiedu therapy, a classic TCM anti - tumor regimen, can regulate the tumor microenvironment, reduce inflammatory mediator levels, and reverse drug resistance with few adverse reactions. This review summarizes the mechanisms and limitations of trastuzumab plus chemotherapy, analyzes the synergistic effects of combined TCM and Western medicine treatment, and shows that Yiqi Huayu Jiedu therapy can alleviate treatment - related toxicities and enhance anti - tumor sensitivity. This combined regimen integrates TCM holistic concepts with modern precision medicine, offering a novel strategy for HER2 - positive endometrial cancer, which is of great value for improving patient survival and quality of life.
subject: Research Article
  topic: section
subject: Endometrial cancer
  topic: keywords
subject: Yiqi Huayu Jiedu therapy
  topic: keywords
subject: Trastuzumab
  topic: keywords
subject: Chemotherapy
  topic: keywords
creator: MengXin Xu
creator: Lei Liu
rights: Copyright (c) 2026 MengXin Xu; Lei Liu https://creativecommons.org/licenses/by/4.0
date: 2026-03-23
publication date: 2026-03-23
starting page: 56
ending page: 59
doi: 10.61784/jpmr3068

MUSCLE ENERGY TECHNIQUE(MET) COMBINED WITH KINESIO TAPING FOR FUNCTIONAL RECOVERY IN PATIENTS WITH ANKLE SPRAIN: A RANDOMIZED CONTROLLED TRIAL
type: item
description: Objective: To evaluate the effects of muscle strength training combined with kinesio taping on pain, swelling, and functional recovery in patients with acute ankle sprain. Methods: Forty patients with acute ankle sprain were randomly assigned to either a control group (muscle strength training alone, n=20) or an experimental group (muscle strength training combined with kinesio taping, n=20). Both interventions were administered once every other day for two weeks. Visual Analog Scale (VAS) for pain, swelling degree (affected limb circumference), and AOFAS ankle-hindfoot function score were assessed before treatment and at days 1, 5, 9, and 14 post-treatment. Results: The experimental group demonstrated significantly lower VAS scores and significantly smaller affected limb circumference compared with the control group at all post-treatment time points (all p < 0.001). The AOFAS total score was significantly higher in the experimental group than in the control group (96.25±5.59 vs. 74.95±10.86, p < 0.001), with significant advantages in pain, daily activities, walking surface, foot alignment, gait, and range of motion subscales (p < 0.05 or p < 0.001). Conclusion: Muscle strength training combined with kinesio taping significantly alleviates pain, reduces swelling, and improves functional recovery in patients with acute ankle sprain, offering a more effective rehabilitation strategy than muscle strength training alone.
subject: Research Article
  topic: section
subject: Ankle sprain
  topic: keywords
subject: Kinesio taping
  topic: keywords
subject: Muscle strength training
  topic: keywords
creator: PengYu Xia
creator: YongPeng Li
creator: HuiDong Ding
rights: Copyright (c) 2026 PengYu Xia; YongPeng Li; HuiDong Ding https://creativecommons.org/licenses/by/4.0
date: 2026-03-23
publication date: 2026-03-23
starting page: 51
ending page: 55
doi: 10.61784/jpmr3067

FROM GUT TO BRAIN: TARGETING THE MICROBIOTA AXIS FOR NOVEL THERAPEUTIC AVENUES IN PARKINSON’S DISEASE
type: item
description: Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, with increasing evidence highlighting a strong link between its pathogenesis and intestinal microbiome dysbiosis. This review systematically elucidates the mechanistic pathways of the microbiota–gut–brain axis in PD, emphasizing how gut dysbiosis promotes α-synuclein misfolding and propagation via the vagus nerve, thereby initiating neuroinflammation and dopaminergic neuronal loss. It further examines the critical role of the microbiota–immune–neural signaling network in driving disease progression. In addition, the therapeutic potential and current limitations of microbiota-targeted interventions, including fecal microbiota transplantation, prebiotics, probiotics, and dietary modulation, are evaluated. Collectively, current evidence highlights the gut–brain axis as a key framework in understanding PD etiology and underscores the intestine as a promising site for early intervention and the development of mechanism-based therapies.
subject: Research Article
  topic: section
subject: Parkinson’s disease
  topic: keywords
subject: Gut microbiota
  topic: keywords
subject: α-synuclein
  topic: keywords
subject: Neurodegenerative disease
  topic: keywords
subject: Neuroinflammation
  topic: keywords
subject: Microecological therapy
  topic: keywords
creator: ShengLi Gu
rights: Copyright (c) 2026 ShengLi Gu https://creativecommons.org/licenses/by/4.0
date: 2026-03-09
publication date: 2026-03-09
starting page: 47
ending page: 50
doi: 10.61784/jpmr3066

EVALUATION OF PERFORMANCE AND SAFETY OF THE 12-LEAD ECG: A PROSPECTIVE SIMULTANEOUS PAIRED COMPARATIVE STUDY
type: item
description: This prospective, paired comparative study aimed to evaluate the diagnostic accuracy and safety of a multi-channel digital ECG system (Zoncare company, E-Series) against a conventional device (ED** company, SE-Series) in a clinical setting. A total of 154 participants were categorized into three groups—normal ECG, arrhythmia, and ST-segment elevation/depression—and underwent sequential ECG recordings with both devices in randomized order. Key parameters, including heart rate, PR interval, QRS duration, QT interval, and the axes of the P wave, QRS complex, and T wave, and ST-segment deviation, were automatically measured by both systems, with ST-deviation also assessed manually. Results indicated no statistically significant differences (P > 0.05) in any parameter between the two devices. Manual evaluation confirmed 100% recognition accuracy of ST-segment elevation or depression by the E-Series, with no significant difference in deviation magnitude (P > 0.05). Automatic measurements exhibited exceptionally high inter-device correlation, with r-values approaching 1 (all P < 0.001). No device-related adverse events were recorded throughout the study. In conclusion, the Zoncare E-Series multi-channel digital ECG system demonstrated diagnostic non-inferiority compared to the conventional reference device across a spectrum of cardiac rhythms and ischemic manifestations, supporting its reliability and safety for clinical electrocardiographic acquisition.
subject: Research Article
  topic: section
subject: Accuracy
  topic: keywords
subject: Electrocardiograph
  topic: keywords
subject: Multichannel
  topic: keywords
subject: ECG parameters
  topic: keywords
subject: ST-segment deviation
  topic: keywords
subject: Arrhythmias
  topic: keywords
subject: Safety
  topic: keywords
creator: Bo Zhang
creator: Tao Zhu
creator: Tao Hu
creator: Jing Li
creator: JiaBing Zhu
creator: ZiYan Wan
rights: Copyright (c) 2026 Bo Zhang; Tao Zhu; Tao Hu; Jing Li; JiaBing Zhu; ZiYan Wan https://creativecommons.org/licenses/by/4.0
date: 2026-02-02
publication date: 2026-02-02
starting page: 21
ending page: 27
doi: 10.61784/jpmr3063

TREM1 PROMOTES GASTRIC CANCER METASTASIS AND LEADS TO POOR PROGNOSIS IN PATIENTS THROUGH THE ERK/IL-6 SIGNALING PATHWAY
type: item
description: Objective: To analyze the expression of TREM1 in gastric cancer tissues and serum of gastric cancer patients, and to explore the link between TREM1 expression levels and the clinical features of patients. Furthermore, to explore the specific mechanism by which TREM1 promotes the metastatic ability of MKN45 cells. Method: Gene expression analysis, differential genes, KEGG enrichment analysis, and immune correlation analysis were performed using TCGA and GEO databases; Compare the concentration of TREM1 in the serum of gastric cancer patients using clinical serum sample standards and group them to analyze the relationship between TREM1 and clinical characteristics and prognosis of patients; Select MKN45 cells, silence the expression of TREM1 and IL-6 using small interfering RNA, overexpress TREM1 using plasmid, and perform corresponding treatments. Compare the changes in cell proliferation and migration ability in different groups using scratch assay and transwell assay; Western blotting was used to detect changes in the ERK signaling pathway, IL-6 expression, and EMT related proteins among different groups; Real time fluorescence quantitative PCR comparison of changes in downstream immune factors of TREM1. Result: TREM1 concentration increased in the serum of gastric cancer patients and was associated with their recurrence, metastasis, and overall survival time; TREM1 promotes invasion and metastasis of MKN45 cells; TREM1 upregulates IL-6 by activating the ERK signaling pathway; TREM1 promotes gastric cancer EMT by upregulating IL-6, leading to enhanced metastatic ability of gastric cancer cells. Conclusion: TREM1 is highly expressed in the serum of gastric cancer patients and upregulates IL-6 by activating the ERK signaling pathway, thereby promoting EMT and invasion and metastasis of gastric cancer, leading to poor prognosis for patients.
subject: Research Article
  topic: section
subject: TREM1
  topic: keywords
subject: IL-6
  topic: keywords
subject: Gastric cancer
  topic: keywords
subject: EMT
  topic: keywords
subject: ERK signaling pathway
  topic: keywords
subject: Recurrence and metastasis
  topic: keywords
creator: ZhiGang Zhai
creator: Yuan Fang
creator: ZhenYu Xue
creator: Jian Guo
creator: Wen Sun
creator: Xiang Tang
rights: Copyright (c) 2026 ZhiGang Zhai; Yuan Fang; ZhenYu Xue; Jian Guo; Wen Sun; Xiang Tang https://creativecommons.org/licenses/by/4.0
date: 2026-01-09
publication date: 2026-01-09
starting page: 8
ending page: 15
doi: 10.61784/jpmr3062

EXPRESSION AND CLINICAL SIGNIFICANCE OF LHPP IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA
type: item
description: Objective: To investigate the expression characteristics, clinical significance and underlying molecular mechanism of phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) in esophageal squamous cell carcinoma (ESCC), and to provide novel potential targets for the diagnosis, prognostic evaluation and clinical treatment of ESCC. Methods: The expression difference of LHPP mRNA between ESCC tissues and adjacent normal tissues was analyzed from the Gene Expression Omnibus (GEO) database including GSE20347, GSE38129 and GSE77861. A total of 15 pairs of ESCC tumor tissues and matched adjacent normal tissues, serum samples from 40 newly diagnosed ESCC patients and 20 healthy volunteers were collected. The expression level of LHPP was detected by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA). Western blot was used to determine the protein expression of LHPP in ESCC cell lines (TE-1, KYSE-30, KYSE-150) and the normal esophageal epithelial cell line Het-1A. The correlation between LHPP expression and survival prognosis of ESCC patients was analyzed based on The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) between LHPP high and low expression groups were screened, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. The characteristics of tumor-infiltrating immune cells, the expression profiles of immune checkpoint genes and the sensitivity to five clinical common chemotherapeutic drugs including paclitaxel were further detected and compared between the two groups. Results: LHPP was significantly down-regulated in ESCC tissues, peripheral serum of ESCC patients and ESCC cell lines (P<0.05). ESCC patients with low LHPP expression had a markedly shortened median survival time (1.5 years vs 2.8 years), and the area under the curve (AUC) values of LHPP for predicting the 1-year, 2-year and 3-year overall survival rates of ES…
subject: Research Article
  topic: section
subject: Esophageal squamous cell carcinoma
  topic: keywords
subject: LHPP
  topic: keywords
subject: Tumor suppressor gene
  topic: keywords
subject: Tumor immune microenvironment
  topic: keywords
subject: Chemotherapeutic sensitivity
  topic: keywords
subject: Prognostic marker
  topic: keywords
creator: ZhiGang Zhai
creator: Yuan Fang
creator: ZhenYu Xue
creator: Jian Guo
creator: Xiang Tang
rights: Copyright (c) 2026 ZhiGang Zhai; Yuan Fang; ZhenYu Xue; Jian Guo; Xiang Tang https://creativecommons.org/licenses/by/4.0
date: 2026-03-06
publication date: 2026-03-06
starting page: 37
ending page: 46
doi: 10.61784/jpmr3065

NURSING EFFECT OF TRADITIONAL CHINESE MEDICINE SMEARING ON RADIATION SKIN INJURY IN A PATIENT WITH BREAST CANCER
type: item
description: This article summarized the nursing effect and experience of a case of skin injury caused by radiotherapy of breast cancer treated with Chinese herbal medicine. Diyu has the effects of cooling blood, stopping bleeding, antibacterial, anti allergic, anti-inflammatory, reducing swelling, antioxidant, improving the blood system and neuroprotection. Diyu ointment is applied to the site of radiation-induced skin injury through traditional Chinese medicine rubbing, and has achieved good results. The patient's site has healed well and is very satisfied with the treatment effect. This ointment has a single ingredient and good therapeutic effect, and can be used by radiation therapy patients for the prevention and treatment of radiation-induced skin damage.
subject: Research Article
  topic: section
subject: Traditional Chinese Medicine application
  topic: keywords
subject: Breast cancer
  topic: keywords
subject: Radiation induced skin damage
  topic: keywords
subject: Nursing
  topic: keywords
creator: XiaoYan Wen
creator: XiuLing Ding
creator: YaLin Guo
creator: Jin Liu
creator: LiLi Jia
rights: Copyright (c) 2026 XiaoYan Wen; XiuLing Ding; YaLin Guo; Jin Liu; LiLi Jia https://creativecommons.org/licenses/by/4.0
date: 2026-01-12
publication date: 2026-01-12
starting page: 16
ending page: 20
doi: 10.61784/jpmr3060

PROGRESS AND MECHANISMS OF ANTIBODY-DRUG CONJUGATES IN NSCLC THERAPY
type: item
description: Antibody–drug conjugates (ADCs) are emerging as a transformative therapeutic modality for non-small cell lung cancer (NSCLC), bridging the tumor selectivity of monoclonal antibodies with the potent cytotoxicity of chemotherapy payloads. This review summarizes recent clinical progress of ADCs in NSCLC and highlights key design features that shape efficacy and safety, including antigen selection, linker chemistry, payload class, drug–antibody ratio, and the bystander effect. Particular emphasis is placed on clinically advanced targets—HER2, TROP2, HER3, and MET—as well as promising emerging antigens such as B7-H3. Across multiple studies, next-generation ADCs have shown meaningful activity in molecularly defined and treatment-refractory populations, including patients with acquired resistance to EGFR-targeted therapy and those harboring HER2 alterations. However, ADC use is constrained by distinctive toxicities, notably interstitial lung disease/pneumonitis associated with certain topoisomerase I inhibitor payloads, alongside myelosuppression and gastrointestinal adverse events. We further discuss evolving resistance mechanisms (antigen downregulation, impaired internalization, efflux transporters, and microenvironmental barriers) and outline future directions, including biomarker-guided patient selection, rational sequencing, and combination strategies with immune checkpoint inhibitors or targeted agents. Collectively, ADCs are poised to become an integral component of precision therapy for NSCLC, contingent on optimized design and proactive toxicity management.
subject: Research Article
  topic: section
subject: Antibody-drug conjugates
  topic: keywords
subject: ADCs
  topic: keywords
subject: NSCLC
  topic: keywords
creator: XiangYu Jia
creator: YunLong Yang
rights: Copyright (c) 2026 XiangYu Jia; YunLong Yang https://creativecommons.org/licenses/by/4.0
date: 2026-02-13
publication date: 2026-02-13
starting page: 28
ending page: 36
doi: 10.61784/jpmr3064

PRETREATMENT ULTRASOUND-BASED RADIOMICS NOMOGRAM FOR PREDICTING PATHOLOGICAL COMPLETE RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN HER2-POSITIVE BREAST CANCER
type: item
description: Background: Accurately predicting pathological complete response (PCR) to neoadjuvant chemotherapy (NAC) in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer is crucial for tailoring individualized treatment strategies. This study seeks to develop and validate a radiomics-based nomogram utilizing pretreatment ultrasound (US) data to predict PCR on an individual basis. Methods: In this retrospective analysis, patients diagnosed with HER2-positive breast cancer who underwent NAC were included and randomly assigned to either a training cohort (70%) or a validation cohort (30%) between January 2020 and December 2024. Radiomics features were extracted from the entire tumor volume as delineated on pretreatment US images. Feature selection was conducted using a combination of stability analysis, the Least Absolute Shrinkage and Selection Operator (LASSO)to establish a comprehensive radiomics signature (Rad-score). A predictive nomogram was then constructed by integrating the Rad-score with independent clinical predictors through multivariate logistic regression. The model's performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration curves, and decision curve analysis (DCA). Results:The radiomics signature, consisting of 10 features derived from first-order statistics and texture matrices, exhibited significant predictive capability, achieving an area under the curve (AUC) of 0.705 in the validation cohort. The final nomogram, integrating the Rad-score, progesterone receptor (PR), demonstrated enhanced performance, with AUCs of 0.749 and 0.744 in the training and validation cohorts, respectively. Calibration curves and decision curve analyses confirmed the model's robust calibration and clinical applicability. Conclusion: The pretreatment ultrasonography-based radiomics nomogram offers a non-invasive and effective tool for the individualized prediction of pathological complete response (PCR…
subject: Research Article
  topic: section
subject: Breast cancer
  topic: keywords
subject: HER2-Positive
  topic: keywords
subject: Neoadjuvant chemotherapy
  topic: keywords
subject: Ultrasonography
  topic: keywords
subject: Radiomics
  topic: keywords
subject: Machine learning
  topic: keywords
creator: FeiFei Shan
creator: JunQi Sun
creator: Wei Zhou
creator: ChengYuan Zheng
rights: Copyright (c) 2025 FeiFei Shan; JunQi Sun; Wei Zhou; ChengYuan Zheng https://creativecommons.org/licenses/by/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 71
ending page: 80
doi: 10.61784/jpmr3059

NON-INVASIVE PRENATAL DETECTION MODEL FOR FEMALE FETAL CHROMOSOMAL ANEUPLOIDY BASED ON XGBOOST
type: item
description: Addressing the challenge of limited accuracy in non-invasive prenatal testing (NIPT) for female fetal chromosomal aneuploidy due to the absence of Y chromosome reference, this study innovatively proposes a multi-feature fusion detection model based on XGBoost. The model's innovations are threefold: first, it constructs a three-dimensional feature system integrating "Z-score-GC content-clinical indicators", breaking through the limitation of traditional methods relying on single chromosomal indicators; second, it leverages XGBoost's powerful capability in capturing nonlinear relationships to deeply explore complex interaction effects among multi-chromosomal features; third, through feature importance ranking, it systematically reveals for the first time the critical roles of GC content in chromosome 13 and Z-scores of chromosomes 18 and X in female fetal abnormality detection. Experimental results demonstrate that the model achieves an accuracy of 75.45%, precision of 75.63%, recall of 75.45%, and F1-score of 75.47%, significantly outperforming traditional methods. This study provides a novel technical approach for detecting female fetal chromosomal aneuploidy with substantial clinical application value.
subject: Research Article
  topic: section
subject: Non-Invasive prenatal testing
  topic: keywords
subject: Chromosomal aneuploidy
  topic: keywords
subject: XGBoost
  topic: keywords
subject: Feature fusion
  topic: keywords
subject: Female fetal detection
  topic: keywords
creator: RuiYing Chen
rights: Copyright (c) 2025 RuiYing Chen https://creativecommons.org/licenses/by/4.0
date: 2025-12-03
publication date: 2025-12-03
starting page: 38
ending page: 43
doi: 10.61784/jpmr3054

REGRESSION ANALYSIS-BASED INVESTIGATION OF FACTORS INFLUENCING MALE FETAL Y CHROMOSOME CONCENTRATION AND STRATIFIED OPTIMIZATION OF OPTIMAL TIMING FOR NON-INVASIVE PRENATAL TESTING
type: item
description: This study systematically analyzed the quantitative relationship between male fetal Y chromosome concentration and maternal gestational age and body mass index, aiming to optimize the timing for non-invasive prenatal testing. To investigate these relationships, gestational age data formats were standardized, and missing BMI values were calculated and imputed. Pearson and Spearman correlation analyses revealed a weak positive correlation between Weeks and, and a weak negative correlation with BMI. Further OLS regression modeling revealed that Weeks exerted a significant positive effect on Y and BMI a significant negative effect , both statistically significant. Although the linear model exhibited low explanatory power and heteroscedasticity, incorporating LOWESS nonlinear smoothing clearly revealed a “rapid-then-slow” increase pattern of Y with Weeks. This confirmed the clinical observation that Y significantly declines when BMI exceeds 30. Subsequently, to determine the optimal testing window, pregnant women were stratified into four BMI groups. Intra-group OLS regression and LOWESS fitting were performed, supplemented by sensitivity analysis using 3.5%, 4.0%, and 4.5% thresholds. Results indicated that detection was feasible around 11–12 weeks for low-BMI women; while high-BMI pregnant women required delaying until approximately 12.5 weeks to achieve stable detection rates. This study provides quantitative evidence for optimizing NIPT testing strategies in clinical practice.
subject: Research Article
  topic: section
subject: Non-invasive prenatal testing
  topic: keywords
subject: Regression analysis
  topic: keywords
subject: Optimal testing timing
  topic: keywords
subject: Y Chromosome Concentration
  topic: keywords
creator: Ting Li
rights: Copyright (c) 2025 Ting Li https://creativecommons.org/licenses/by/4.0
date: 2025-12-03
publication date: 2025-12-03
starting page: 30
ending page: 37
doi: 10.61784/jpmr3053

THE ANIMAL MODEL ESTABLISHMENT METHODS AND MODEL EVALUATION FOR LIVER STAGNATION AND SPLEEN DEFICIENCY SYNDROME
type: item
description: The fast pace of modern life has increased stress, leading to a faster incidence of liver qi stagnation and spleen deficiency syndrome in diseases. Therefore, liver qi stagnation and spleen deficiency syndrome has become a common clinical syndrome. Animal models of liver qi stagnation and spleen deficiency syndrome are used in various disease areas, and numerous methods exist for evaluating these models, resulting in problems such as confusion regarding counter-evidence formulas. This article mainly evaluates the modeling methods, behavioral testing methods, and counter-evidence formulas for liver qi stagnation and spleen deficiency syndrome in various diseases, providing theoretical support for experimental research on this syndrome.
subject: Research Article
  topic: section
subject: Liver qi stagnation and spleen deficiency syndrome
  topic: keywords
subject: Animal model
  topic: keywords
subject: Counter-evidence formula
  topic: keywords
subject: Behavioral science
  topic: keywords
subject: Tail clamping
  topic: keywords
subject: Restraint
  topic: keywords
creator: Feng Wang
creator: HuiYong Zhang
creator: GuanLin Yang
rights: Copyright (c) 2025 Feng Wang; HuiYong Zhang; GuanLin Yang https://creativecommons.org/licenses/by/4.0
date: 2025-11-29
publication date: 2025-11-29
starting page: 25
ending page: 29
doi: 10.61784/jpmr3052

ANALYSIS OF THE STATUS OF NEWLY REPORTED OCCUPATIONAL DISEASES IN EMPLOYING UNITS IN A CERTAIN CITY FROM 2015 TO 2024
type: item
description: Objective: To analyze the epidemiological characteristics and trends of newly reported occupational diseases among employing units in a certain City from 2015 to 2024, and to provide a scientific basis for developing targeted occupational disease prevention and control strategies. Methods: A retrospective epidemiological investigation was conducted. Data from 469 newly reported occupational disease cases in a certain City between 2015 and 2024 were collected from the occupational disease reporting system. Descriptive epidemiological methods and statistical analyses (chi-square test, analysis of variance) were employed to analyze the distribution characteristics and trends of occupational diseases. Results: Pneumoconiosis was the predominant occupational disease in a certain City, accounting for 95.10% of all cases. Among these, coal workers' pneumoconiosis (316 cases, 67.38%) and silicosis (130 cases, 27.72%) were the most common. The year 2019 marked the peak incidence (89 cases), with a fluctuating downward trend observed in recent years. A significant difference was found in the average length of exposure before onset among different occupational diseases (F = 11.41, P = 0.001), with coal workers' pneumoconiosis having the longest average exposure period (25.66 ± 6.63 years). Conclusions: While certain achievements have been made in occupational disease prevention and control in a certain City, pneumoconiosis remains the primary concern. Targeted prevention and control measures should be strengthened in high-risk areas and industries, and for specific exposure length groups. Additionally, emerging occupational health risks require ongoing attention.
subject: Research Article
  topic: section
subject: Energy city
  topic: keywords
subject: Occupational diseases
  topic: keywords
subject: Incidence trend
  topic: keywords
creator: Wei Gao
creator: Yong Zhang
creator: Xin Ge
rights: Copyright (c) 2025 Wei Gao; Yong Zhang; Xin Ge https://creativecommons.org/licenses/by/4.0
date: 2025-11-26
publication date: 2025-11-26
starting page: 20
ending page: 24
doi: 10.61784/jpmr3051

MECHANISM STUDY OF SHENFU INJECTION REGULATING MAPK PATHWAY TO ALLEVIATE MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RATS BASED ON BIOINFORMATICS AND EXPERIMENTAL VERIFICATION
type: item
description: To elucidate SFI’s protective mechanism against MIRI, this study identified the MAPK pathway via bioinformatics. Experimental validation in MIRI rats confirmed that SFI improves myocardial injury by suppressing MAPK activation and inflammatory factors (IL-1β, IL-6, TNF-α), supporting its clinical potential.
subject: Research Article
  topic: section
subject: Shenfu Injection (SFI)
  topic: keywords
subject: Myocardial Ischemia-Reperfusion Injury (MIRI)
  topic: keywords
subject: Mitogen-Activated Protein Kinase (MAPK) signaling pathway
  topic: keywords
subject: Bioinformatics
  topic: keywords
subject: Inflammatory factors
  topic: keywords
creator: Hong Wang
creator: Liu Yang
creator: HuaiGang Chen
creator: GaoMing Hong
creator: ShengQiang Zeng
creator: WenYan Xu
creator: Yao Hu
rights: Copyright (c) 2025 Hong Wang; Liu Yang; HuaiGang Chen; GaoMing Hong; ShengQiang Zeng; WenYan Xu; Yao Hu https://creativecommons.org/licenses/by/4.0
date: 2025-11-14
publication date: 2025-11-14
starting page: 15
ending page: 19
doi: 10.61784/jpmr3048

EXPRESSION AND CLINICAL SIGNIFICANCE OF GLYCEROL KINASE (GK) IN ESOPHAGEAL CARCINOMA
type: item
description: Objective: This study aimed to investigate the expression of glycerol kinase (GK) in esophageal carcinoma tissues and cell lines, and to explore its correlation with clinical characteristics and patient prognosis. Methods: Public databases (TCGA, GTEx) and clinical specimens were used to validate GK expression in esophageal carcinoma tissues. The KYSE150 cell line was selected for GK knockdown experiments. Cell proliferation and migration were assessed using CCK-8 and Transwell assays, respectively. R language was employed to analyze correlations between GK expression and immune checkpoint molecules, as well as the tumor immune microenvironment. Results: GK mRNA and protein expression levels were significantly elevated in esophageal carcinoma tissues compared to adjacent normal tissues. Patients with high GK expression had significantly shorter overall survival than those with low expression. Clinical analysis revealed that high GK expression was strongly associated with distant metastasis and tumor recurrence. In vitro experiments demonstrated that GK knockdown suppressed proliferation and migration of esophageal carcinoma cells. Bioinformatic analysis indicated that high GK expression correlated with upregulation of immune checkpoint molecules (e.g., CD274, CTLA4, LAG3) and reduced infiltration of CD8+ T cells. Conclusion: GK is highly expressed in esophageal carcinoma and promotes malignant progression by enhancing tumor cell proliferation, migration, and participation in an immunosuppressive microenvironment. GK may serve as a potential prognostic biomarker and therapeutic target.
subject: Research Article
  topic: section
subject: GK
  topic: keywords
subject: ESCA
  topic: keywords
subject: Immune microenvironment
  topic: keywords
subject: Survival prognosis
  topic: keywords
creator: Yuan Fang
creator: ZhenYu Xue
creator: Jian Guo
creator: Wen Sun
creator: Xiang Tang
rights: Copyright (c) 2026 Yuan Fang; ZhenYu Xue; Jian Guo; Wen Sun; Xiang Tang https://creativecommons.org/licenses/by/4.0
date: 2026-01-09
publication date: 2026-01-09
starting page: 1
ending page: 7
doi: 10.61784/jpmr3061

ADVANCES IN THE APPLICATION OF DEEP LEARNING IN CERVICAL OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT
type: item
description: Cervical ossification of the posterior longitudinal ligament (OPLL) is relatively common among Asian populations. Its progression can cause spinal canal stenosis and compression of the spinal cord and nerve roots, leading to neurological dysfunction and increasing surgical complexity and the risk of complications. In recent years, early identification, precise evaluation, and appropriate intervention for OPLL have become major focuses in radiology and spine surgery. Artificial intelligence, particularly deep learning, has shown new potential in the detection, lesion segmentation, and prognostic evaluation of this disease. This article integrates existing studies to summarize the advances of deep learning in multimodal imaging and discusses its value in clinical decision support, aiming to provide methodological references and clinical insights for related disciplines.
subject: Research Article
  topic: section
subject: Deep learning
  topic: keywords
subject: Cervical ossification of the posterior longitudinal ligament
  topic: keywords
subject: Multimodal medical imaging
  topic: keywords
subject: Risk prediction
  topic: keywords
creator: ZhongLiang Wang
creator: Xiang Guo
rights: Copyright (c) 2025 ZhongLiang Wang; Xiang Guo https://creativecommons.org/licenses/by/4.0
date: 2025-11-13
publication date: 2025-11-13
starting page: 9
ending page: 14
doi: 10.61784/jpmr3049