Integrative Bioinformatics (IB) is an international peer-reviewed, open access journal.
ANALYSIS OF OXIDATIVE STRESS-RELATED GENES IN MAJOR DEPRESSION BASED ON BIOINFORMATICS AND SCREENING OF TARGETED PREVENTION AND TREATMENT OF TRADITIONAL CHINESE MEDICINES
Major Depressive Disorder (MDD) is a severe mental disorder with approximately 350 million patients worldwide. In recent years, oxidative stress has played an important role in the pathogenesis of depression. This study used bioinformatics methods to explore the expression patterns of oxidative stress-related differential genes in MDD and screen related traditional Chinese medicines, in order to provide more reference for clinical decision-making.
Copyright (c) 2024 Rando Grace https://creativecommons.org/licenses/by/4.0
THE ROLE OF PROTEIN REGULATING CYTOKINESIS 1 IN THE MANAGEMENT OF GASTROINTESTINAL TUMORS
Objective: To investigate the expression patterns, biological functions, and prognostic significance of protein regulating cytokinesis 1 (PRC1) in gastrointestinal tumors using bioinformatics approaches, thereby providing potential guidance for clinical management. Methods: Publicly available databases were used to analyze PRC1 expression levels in gastrointestinal tumors. Co-expressed genes, underlying biological mechanisms, immune regulatory characteristics, mutation sites, and mutation types of PRC1 were systematically evaluated. In addition, the prognostic value of PRC1 expression and gene mutations was assessed across multiple tumor types, with a specific focus on gastrointestinal malignancies. Results: PRC1 was highly expressed in cholangiocarcinoma, colorectal cancer, hepatocellular carcinoma, pancreatic cancer, rectal cancer, and gastric cancer. PRC1 and its co-expressed genes jointly influenced key biological processes in gastrointestinal tumors. Gene Ontology (GO) enrichment analysis revealed that PRC1-related gene sets were predominantly enriched in mitosis-related pathways. Immunological analyses indicated that PRC1 was involved in the regulation of B cells, CD4? T cells, CD8? T cells, and other immune cells in gastric and pancreatic cancers. PRC1 alterations, including deep deletion, shallow deletion, diploid mutation, and amplification, affected tumor biological processes. Missense mutations and truncations were the predominant mutation types, influencing PRC1 translation and expression. High PRC1 expression was associated with poor prognosis in gastric and pancreatic cancers, and patients with PRC1 mutations exhibited worse clinical outcomes. Conclusion: Aberrant expression and mutation of PRC1 are associated with malignant progression and unfavorable prognosis in gastrointestinal tumors, highlighting PRC1 as a potential prognostic biomarker and therapeutic target for guiding clinical treatment strategies.
Copyright (c) 2025 WangFeng Lin https://creativecommons.org/licenses/by/4.0